Oligosaccharyltransferase-Subunit Mutations in Nonsyndromic Mental Retardation

Protein Implicated in Nonsyndromic Mental Retardation Regulates Protein Kinase A (PKA) Activity

Mutation of the coiled-coil and C2 domain-containing 1A (CC2D1A) gene, which encodes a C2 domain and DM14 domain-containing protein, has been linked to severe autosomal recessive nonsyndromic mental retardation. Using a mouse model that produces a truncated form of CC2D1A that lacks the C2 domain and three of the four DM14 domains, we show that CC2D1A is important for neuronal differentiation a...

Mental Retardation

This small book is the first of a series of occasional papers which are to be published under the auspices of the Institute for Research into Mental Retardation, and its author is the chairman of the Institute's Research Committee. In the preface, it is said to be aimed at an intelligent lay audience and it is suggested that 'it will be read with interest and profit by workers in the field of m...

Mental Retardation in Children

One hundred and eighty three children suffering from mental retardation were studied over a period of 17 months (December’80 April’82). Mental retardation in 101 cases (5 5.2%) was due to preventable causes i.e. tubercular meningitis, birth trauma, encephalitis, cretinism and kernicterus. Majority of them belonged to lower socio-economic group and had no access to medical facilities, therefore ...

Mental Retardation

title. A book on molecular pharmacology should be concerned primarily with drug-receptor interactions in terms of small molecule-biopolymer interactions. Yet, this text discusses neither protein structure nor nucleic acid structure and minimizes discussions of drug induced conformational changes. In other words, this volume is a good textbook of nonmolecular pharmacology. In the introduction th...

Mental Retardation